Serious Sam 2 Patch
Serious Sam: The Second. Serious Sam: The Second Encounte. More Serious Sam: The Second Encounter Fixes. Serious Sam 2 v2.068 ENG.
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Serious Sam 2
Search for related No-CD & No-DVD Patch
No-CD & No-DVD Patch troubleshooting: The most common problem getting a No-CD/No-DVD patch to work is ensuring that the No-CD/No-DVD patch matches you're game version, because the games exe is changed when a patch update is applied previous versions won't work.
Serious Sam 2 Download
If its an older game you are playing and you are running Windows 7 or Windows 8 it may not work, if you right click the .exe file and choose Properties and then Compatibility you can change this to run in Windows 98/ Windows 2000 etc. You can find more information on the Beginners Help page here